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Friday, January 30, 2009

Here's what I did all day

I'm not editing the following paragraph. I'm reading the article it came from. It's from a journal article I have to read (along with about 12 other similar pieces) in order to write the brief articles I write for a health providers newsletter.

C-reactive protein was discovered and named for its binding to pneumococcal somatic C-polysaccharide [29] in which it recognizes the phosphocholine residues which are present in this ribitol teichoic acid [30]. Phosphocholine is the natural ligand to which CRP binds with highest affinity and this key ligand is ubiquitous as the polar head group of phosphatidlyl choline in cell membranes and plasma lipoproteins. Phosphocholine is also present in constituents of many bacteria, fungi and parasites and plants and the importance for mammalian biology of its recognition is exemplified by the fact that a significant proportion of the germline antibody specificities are directed at it. However, CRP does not bind to all materials containing phosphocholine as the residues must be 'available' or in an appropriate sterochemical configuration. Thus CRP binds to dead or damaged cells in which significant amounts of lysophosphatidyl choline are present, but not the surface of living healthy cells [31]. Binding of CRP to apoptotic cells is controversial and the most rigorous evidence suggests that CRP only binds to so-called late apoptotic cells which are effectively necrotic [32–34]. CRP also binds to oxidized phospholipids [33], platelet activating factor [35], modified LDL [36], β-VLDL, concentrated normal VLDL [37] and to small nuclear ribonucleoprotein particles (which do not contain phosphocholine) when these are exposed in dead or damaged cells [38, 39].

That and watch the dog. I was an English major, for crying out loud. I think my brain just went necrotic.


  1. CRP is suffering from low self esteem, don'tcha think? :)

    "Thus CRP binds to dead or damaged cells in which significant amounts of lysophosphatidyl choline are present, but not the surface of living healthy cells [31]".

    It kinda reminds me of Anna Nicole when she married that old, dying rich guy.

    Peace - Rene

  2. I can honestly say I have never seen a paragraph so full of CRP.

    Ah, but the cause for your necrosis may also be the cure! The authors seem to indicate that if you fill your head with more CRP, it will bind to the necrotic cells... could we then flush out the CRP, leaving only healthy brain cells?

  3. I'm all for flushing out the CRP Rab. It's worth a try.

  4. CRP = Can't Read Paragraph

    I can honestly say that I am dumber after reading that.

    Maybe the author of the journal is doing a medical experiment to see if reading this material causes aneurysms. I think it's working on me. Add me to the case study!

  5. Stop it, Lianne. Youre making me laugh so hard I can't concentrate.

  6. Even skimming it primes me for a major episode of something terribly neurotic in nature.

  7. That paragraph is way over my reading level.

  8. I believe a significant proportion of my germline antibody has become infected. Please warn readers!:-)

  9. Grandpa- Gee, and I to think I ENVIED your job!
    I habitally edit everything I read (God knows lots of "professional" writing today needs it!)
    but that sentence made me want to pick fruit instead. . .How do you abstract THAT? Share-

  10. They lost me at the first sentence.
    Let's just say that the writer of this piece would have so little in common with me, we'd probably never have coffee.

  11. My brain cells are definitely damaged now.

  12. I couldn't even get past the second sentence of that! Good luck wading through . . .

  13. I know I'm late to comment. I read absolutely every word --- and it was all CRP to me. Oops, left out the 'A' between the 'R' and the 'P'. How do you do this for a living??? LOL

  14. I couldn't get past "polysaccharide [29]." You are a better man than I am. I mean reader. It's worse than the tax code.

  15. I want to be a polar head group.

    I think the insertion of a comma here:

    "many bacteria, fungi and parasites and plants and"

    after "plants" and before "and" would help for clarification - but not very much.

  16. I'm not terribly religious, but after "reading"* that piece, I just want you to know that my prayers are with you.


    *Can one actually read such glop?